At present times, good immune system is the major weapon against the COVID-19 and vitamins help in efficient functioning of immune system. Inadequacy of these vitamins in the body can lead to suppressed immunity, which may further predispose the patient towards infection. These vitamins enhance the three level of immunity in body’s defense system by supporting physical barriers (skin/mucosa), cellular immunity and antibody production. Vitamins like A, C and E help in enhancing the skin barrier function. Vitamins A, B6, B12, C, D and E work synergistically to support the protective activities of the immune cells. Vitamin A has been shown to enhance immune response against influenza virus.